2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154499
    Methyl 4-C-hydroxymethyl-2,3-O-isopropylidene-beta-D-ribofuranoside
    Methyl 4-C-hydroxymethyl-2,3-O-isopropylidene-beta-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Methyl 4-C-hydroxymethyl-2,3-O-isopropylidene-beta-D-ribofuranoside
  • HY-122427
    Xylocytidine
    Xylocytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    Xylocytidine
  • HY-154449
    N4-Benzoyl-3’-O-(2-methoxyethyl)-5-methylcytidine
    N4-Benzoyl-3’-O-(2-methoxyethyl)-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-3’-O-(2-methoxyethyl)-5-methylcytidine
  • HY-152606
    N6-Ethyl-2’-C-methyladenosine
    N6-Ethyl-2’-C-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Ethyl-2’-C-methyladenosine
  • HY-154220
    N4-Benzoyl-2’-deoxy-2’,2’-diflurocytidine
    N4-Benzoyl-2’-deoxy-2’,2’-diflurocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-2’-deoxy-2’,2’-diflurocytidine
  • HY-152718
    4-Amino-1-(2-C-methyl-β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
    4-Amino-5-cyano-1-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Amino-1-(2-C-methyl-β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • HY-131847
    2,6-Dichloro-2',3',5'-triacetyl-purine riboside
    2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2,6-Dichloro-2',3',5'-triacetyl-purine riboside
  • HY-137576
    DMT-dI Phosphoramidite
    		98.15%
    Phosphoramidite is a modified phosphoramidite monomer used for the oligonucleotide synthesis.
    DMT-dI Phosphoramidite
  • HY-154150
    N-(1-Oxopropyl)cytidine
    N-(1-Oxopropyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    N-(1-Oxopropyl)cytidine
  • HY-152518
    2’-O-Methyl-5-methyl-4-thiouridine
    2’-O-Methyl-5-methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Methyl-5-methyl-4-thiouridine
  • HY-152797
    N4-Desmethyl-N5-Methyl wyosine
    N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    N4-Desmethyl-N5-Methyl wyosine
  • HY-154320
    3’-Azido-3’-deoxy-3-deazauridine
    3’-Azido-3’-deoxy-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-3-deazauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-3-deazauridine
  • HY-152387
    8-Chloro-arabinoadenosine
    8-Chloro-arabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Chloro-arabinoadenosine
  • HY-152349
    2’-Deoxy-2’-fluoro-β-D-arabino-2-thiouridine
    2’-Deoxy-2’-fluoro-β-D-arabino-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-β-D-arabino-2-thiouridine
  • HY-154525
    2’-Deoxy-2’-(N-trifluoroacetyl)amino-5’-O-DMTr-uridine 3’-CED phosphoramidite
    2’-Deoxy-2’-(N-trifluoroacetyl)amino-5’-O-DMTr-uridine 3’-CED phosphoramidite is a uridine analog.
    2’-Deoxy-2’-(N-trifluoroacetyl)amino-5’-O-DMTr-uridine 3’-CED phosphoramidite
  • HY-154736
    N3-(Butyn-3-yl)uridine
    N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents. N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N3-(Butyn-3-yl)uridine
  • HY-152745
    2’-β-C-Methyl-5-trifluoromethyluridine
    2’-β-C-Methyl-5-trifluoromethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-β-C-Methyl-5-trifluoromethyluridine
  • HY-180773
    Formylphosphonic acid
    Formylphosphonic acid is a nucleoside metabolite.
    Formylphosphonic acid
  • HY-152392
    2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine
    2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine
  • HY-152879
    5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyluridine
    5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyluridine